Qlucore Insights (RoU)
AI-based disease subclassification
Advances in precision medicine require powerful yet accessible tools and methods that unite common research goals with collaborative effort. Qlucore Insights is a powerful and flexible software platform that enables implementation of disease-specific tests (models) for subtype classification using whole transcriptomic data and gene expression-based signatures. The test also includes comprehensive gene fusion detection. Whole transcriptomic data is future proof and not hampered by fixed panel limitations. Frontline labs doing research now have a powerful yet user-friendly tool for transforming clinical data into new insights, enabling new RNA-seq, transcriptomic-based or molecular-based findings. Further, researchers can use it to build and evaluate new models, or as the starting point for companion diagnostics.
Use case: Pediatric leukemia
A team at Rigshospitalet, Copenhagen, Denmark has implemented the use of Qlucore Insights for in-house use, in accordance with Article 5(5) in EU IVDR, and included it in the RNA lab workflow for analysis of pediatric leukemia. As data input, whole RNA sequencing data (WTS) from diagnostic ALL samples were used.
Available tests (RoU)
Four tests with significant performance are available, using both gene expression subtyping and gene fusion analysis.
- Pediatric Leukemia (BCP-ALL). Up to 7% more samples are covered compared to standard methods.
- Acute Myeloid Leukemia (AML). Molecular subtype identification combined with cost efficient gene fusion detection in one test
- Lung Cancer. A cost efficient and complete solution for classification of lung lesions including detection of metastasis.
- Bladder Cancer. Avoid human uncertainties and improve risk scoring.
Test details
RNA-seq analysis software for better insights
Qlucore Insights enables disease specific subtype classification and first-class gene fusion analysis support of individual samples. Depending on test the solution works both for FFPE and fresh frozen input material. The wet lab workflow is similar for all tests and is based on Illumina RNA-seq kits. The bioinformatic pipeline uses open-source tools.
Qlucore Insights is an easy-to-use software that takes RNA-seq data as input to generate a report with subtype probabilities as well as detected gene fusions. The classification is done using a machine learning classifier with gene expression levels as input. . Qlucore Insights is a flexible platform that allows users to choose from a range of disease-specific tests. The tests plug into the Qlucore Insight platform and create one unified solution for the lab to perform research on a range of tumor types.
Reporting with visualization
The subtype classification is complemented with visualizations which put the sample in context with reference data. Complementing the reports with easy-to-interpret visualizations improves the analysis and communication.
Videos
Qlucore Insights for BCP-ALL
Qlucore Insights is our software for clinical data analysis. It supports a broad range of tests. This demonstration focus on pediatric leukemia. The t...
Qlucore Insights for Lung Cancer
Qlucore Insights is our software for clinical data analysis. It supports a broad range of tests. This demonstration focuses on lung cancer lesions. Th...
Introduction
Qlucore Insights
A product transforming clinical data into new insights to aid clinicians and lab personnel in their work with precision medicine.The program supports ...
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How it works
The program includes AI powered subtype classification of individual samples, with flexible visualization and comprehensive reporting. Additionally the user-friendly interface for exploration of detected gene fusions and database integration provides a future proof solution adapting to new medical findings.
